Search results for "general [Ray burst]"

Single-cell analysis of population context advances RNAi screening at multiple levels

2012

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…

Durationsförhållandena i finskspråkiga gymnasisters uttal av L2-svenska : hur relaterar de till begripligheten?

2019

Firms’ distance to the European productivity frontier

2022

AbstractIn this article we explore the factors contributing to reduce the distance of laggard firms to the European frontier, focusing on institutional factors. To characterize Total Factor Productivity frontier firms within industries for the European Union we use firm level data from AMADEUS for the period 2003–2014. Our findings provide evidence on the importance of governance quality and easiness in getting credit in explaining the distance of laggard firms to the European productivity frontier. We also find that other factors at the country level -tertiary education, R&D stock, and trade openness- and at the firm level -size, age, and capital-intensity- influence the distance of la…

El uso de órdenes con volumen oculto en el Sistema de Interconexión Bursátil Español

2008

ResumenMuchos mercados dirigidos por órdenes permiten a sus participantes introducir órdenes límite en las que no se revela el tamaño completo de la orden. En este artículo, se describe la utilización de este tipo de órdenes en el mercado español de acciones. Se muestra que una de cada cinco transacciones realizadas en el mercado español implica la detección de volumen oculto. La contribución del volumen oculto al proceso de negociación es más importante entre las acciones menos líquidas, y durante períodos de elevado riesgo de exposición de las órdenes limite. Además, se muestra que los usuarios de este tipo de órdenes se comportan como cazadores de tendencias y siguen un comportamiento im…

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

2021

Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…

An evaluation of cool season turfgrassess in order to identify the species and varieties most suitable for the Mediterranean environment

2004

The cultivars of cool season Graminae species diffusely used to establish turfgrasses, are grown in northern areas of Europe. The aim of the research described in this paper was to identify the turfgrass species and cultivars most suitable for the Mediterranean environment. The trial was carried out in 1999 and 2000 at the experimental farm “Parco d’Orleans” belonging to the Department A.C.E.P. of University of Palermo. During the trial sixty different cultivars of cool season turf species were compared – 20 cultivars of Festuca arundinacea Schreb., 20 cultivars of Poa pratensis L., and 20 cultivars of Lulium perenne L. The main biometric and qualitative parameters examined were ground cove…

The associations of quantitative/qualitative job insecurity and well-being: The role of self-esteem.

2019

Job insecurity is recognized as one of the most prominent job stressors for employees. Despite decades of research, the concurrent examination of both quantitative (i.e. perceived threat of job loss) and qualitative (i.e., perceived threat of losing some job features) job insecurity and the analysis of their different relationships with well-being at work have received relatively scarce attention. This study examined a moderated mediation model of the relationship between quantitative job insecurity and well-being at work. In doing so, the focus was on the mediating effects of qualitative job insecurity and the moderating effects of self-esteem in the abovementioned relationships. Drawing f…

Empowering Absence? Assessing the Impact of Transnational Male Out-Migration on Left behind Wives

2023

Experiences of left-behind family members of transnational migrant workers have been in the shadow of academic discourse on migration. To contribute to the slowly growing body of literature, this study explores the impact of male out-migration on left-behind wives. The study proposes and applies a novel framework to estimate Women Empowerment Index (WEI) for comparing the empowerment level across households with and without men in transnational labor. Cross-sectional surveys and unstructured interviews were used to collect data from 373 respondents from three selected areas in Nepal. Results indicate that left-behind wives experience a higher degree of decision-making authority, physical mo…

American institutionalism at Chicago: A documentary note

2012

This note provides new evidence concerning American institutionalism at Chicago during the 1920s and 1930s. © 2012 Copyright Taylor and Francis Group, LLC.

The drivers of customer satisfaction for academic library services: managerial hints from an empirical study on two Italian university libraries usin…

2015

The intent of this qualitative research is to investigate and understand the requisites of customer satisfaction for academic libraries’ users and to give managerial hints for the implementation of user centred academic library services. To this aim, we analyse the library services of two Italian Universities (the Faculty of Economics of University of Palermo and the Central Library of the University of Salerno) to find relations and congruencies and to evaluate the perceived relevance of the tangible and intangible aspects of these services. In the preliminary phase of the research, we conducted both focus groups and individual interviews involving students or researchers who regularly use…